Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 10/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107465 | 0.83 | ANPEP (0.47) | GAASMN1; SMN2ALDH1A1KDM4EPTGS2 | |
| SCHEMBL8113450 | 0.80 | GAA (0.66) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL6570519 | 0.73 | GAA (1.00) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL10135121 | 0.71 | GAA (0.68) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL27822637 | 0.71 | GAA (0.72) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL8622747 | 0.71 | GAA (0.72) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL6634562 | 0.69 | ALOX5 (0.61) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL10630543 | 0.69 | MEN1 (0.55) | GAASMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL10434862 | 0.68 | GAA (0.68) | GAASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL10117735 | 0.68 | GAA (0.68) | GAASMN1; SMN2LMNAALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | claimed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | claimed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |