Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097957 | 0.83 | GAA (0.57) | PTGS2ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL3634514 | 0.70 | KMT2A (0.49) | PTGS2ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL26503455 | 0.70 | ANPEP (0.62) | ANPEPALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL20984200 | 0.69 | PTGS2 (0.64) | PTGS2ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL425146 | 0.68 | PTGS2 (0.62) | PTGS2ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL2831390 | 0.68 | PTGS2 (0.67) | PTGS2ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL7415077 | 0.68 | MMP9 (0.53) | MMP9MMP2MMP3HTTMMP13 | |
| SCHEMBL11583393 | 0.68 | AAK1 (0.62) | ANPEPALDH1A1KMT2AHTT | |
| SCHEMBL14518056 | 0.67 | L3MBTL1 (0.63) | PTGS2ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4028705 | 0.67 | PTGS2 (0.60) | PTGS2ALDH1A1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |