SCHEMBL809832

SCHEMBL809832

FC(F)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP19A1 P11511 8/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
TSHR P16473 1/20 0.48
MAPK1 P28482 1/20 0.48
HIF1A Q16665 1/20 0.48
MIF P14174 1/20 0.39
IDO1 P14902 1/20 0.38
KCNH2 Q12809 1/20 0.38
TMEM97 Q5BJF2 1/20 0.38
AHR P35869 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7938599 0.89 TSHR (0.48) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL9263367 0.87 CA1 (0.42) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL28777340 0.81 CYP19A1 (0.55) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL196588 0.81 CYP19A1 (0.55) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL5401000 0.81 LMNA (0.50) LMNACYP2A6CYP19A1MEN1KMT2A
Phosphine SCHEMBL28854143 0.79 CYP19A1 (0.53) LMNACYP2A6CYP19A1MEN1KMT2A
Water SCHEMBL28855946 0.79 CYP19A1 (0.53) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL12869567 0.79 LMNA (0.47) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL11458379 0.79 TSHR (0.52) LMNACYP2A6CYP19A1MEN1KMT2A
SCHEMBL11293097 0.79 TSHR (0.52) LMNACYP2A6CYP19A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1693405-B1 PROTON CONDUCTING MEMBRANE AND PROCESS FOR PRODUCING THE SAME JSR CORP (JP) 2012-05-02 EP disclosed
EP-1845122-B1 POLYARYLENE, PROCESS FOR PRODUCING THE SAME, SOLID POLYELECTROLYTE, AND PROTON-CONDUCTIVE FILM JSR CORP (JP) 2011-11-16 EP disclosed
US-8058365-B2 Proton conducting membrane and process for producing the same JSR CORPORATION (JP) 2011-11-15 US disclosed
US-8039165-B2 Proton conductive membrane comprising a copolymer JSR CORPORATION (JP) 2011-10-18 US disclosed
US-7981566-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2011-07-19 US disclosed
US-7893303-B2 Polyarylene, process for producing the same, solid polyelectrolyte, and proton-conductive film JSR CORPORATION (JP) 2011-02-22 US disclosed
US-20100190088-A1 MEMBRANE ELECTRODE ASSEMBLY AND POLYMER ELECTROLYTE FUEL CELL THEREWITH HONDA MOTOR CO., LTD. (JP) 2010-07-29 US disclosed
US-7727652-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2010-06-01 US disclosed
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
EP-1575115-B1 Polymer electrolyte and proton conductive membrane HONDA MOTOR CO LTD (JP) 2010-02-03 EP disclosed
US-6632949-B2 Difluoro-diamine methylene derivatives MITSUI CHEMICALS, INC. (JP) 2003-10-14 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-20030004348-A1 Halogenating agents SONODA HIROSHI (JP) 2003-01-02 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed
US-6458990-B1 BIS(DIHYDROCARBYLAMINO)DIFLUOROMETHANE OR CYCLIC DERIVATIVES THEREOF; FORMING BY REACTING ALKALI METAL HALIDE WITH THE CORRESPONDING AMIDINIUM SALT; FLUORINATION OF ALCOHOLS, THIOPHENOLS, ALDEHYDES, AND KETONES MITSUI CHEMICALS, INC. (JP) 2002-10-01 US disclosed
US-20020042521-A1 Nitrogen-based halogenating agents and process for preparing halogen-containing compounds SONODA HIROSHI (JP) 2002-04-11 US disclosed
US-6329529-B1 FOR FLUORINATING OF ORGANIC COMPOUNDS, EFFICIENCY, POLLUTION CONTROL MITSUI CHEMICALS, INC. (JP) 2001-12-11 US disclosed
EP-0895991-A2 Halogenating agent Mitsui Chemicals, Inc. (JP) 1999-02-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030004348-A1 Halogenating agents AFF1, NAF1, AFF2 LMNA 4101/4885CYP2A6 331/4885CYP19A1 268/4885
US-20020042521-A1 Nitrogen-based halogenating agents and process for preparing halogen-containing compounds AFF1, NAF1, CYP2F1 LMNA 3883/4885CYP2A6 374/4885CYP19A1 289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.