Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926872 | 0.88 | POLB (0.42) | POLBPIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8212701 | 0.87 | PIK3CA (0.42) | POLBPIK3CDPIK3CAMTOR | |
| SCHEMBL8221081 | 0.85 | PIK3CA (0.47) | POLBPIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8206190 | 0.83 | PIK3CD (0.43) | PIK3CDPIK3CAMTORMEN1ALDH1A1 | |
| SCHEMBL8084637 | 0.82 | CA12 (0.45) | PIK3CDPIK3CAMTORMEN1ALDH1A1 | |
| SCHEMBL8098332 | 0.82 | PIK3CA (0.48) | PIK3CDPIK3CAMTORMEN1MAPT | |
| SCHEMBL8216900 | 0.82 | PIK3CA (0.50) | POLBPIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8091889 | 0.82 | PIK3CA (0.48) | POLBPIK3CDPIK3CAMTORMEN1 | |
| SCHEMBL8222645 | 0.79 | POLB (0.42) | POLBPIK3CDPIK3CAMEN1ALDH1A1 | |
| SCHEMBL8206186 | 0.79 | RAB9A (0.45) | POLBPIK3CDPIK3CAMTORALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |