Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726699 | 1.00 | LMNA (0.66) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL5585560 | 0.85 | ABCG2 (0.69) | LMNAMAPK1ABCG2TNFRSF1AMAPT | |
| SCHEMBL5585564 | 0.85 | ABCG2 (0.69) | LMNAMAPK1ABCG2TNFRSF1AMAPT | |
| SCHEMBL9806815 | 0.84 | LMNA (0.61) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL9806817 | 0.84 | LMNA (0.61) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL9037753 | 0.83 | MAPT (0.54) | LMNAMAPK1HTTABCG2TNFRSF1A | |
| SCHEMBL6620113 | 0.82 | HTT (0.67) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL3606864 | 0.82 | MAPT (0.76) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL3606868 | 0.82 | MAPT (0.76) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL5585477 | 0.81 | ALDH1A1 (0.59) | LMNAHTTRAB9AABCG2TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048896-A | FOR TREATMENT OF BRAIN OR NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-04-11 | — | — | US | disclosed |
| EP-0858442-A1 | 4-PHENYL-4-OXO-2-BUTENOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997017316-A1 | 4-PHENYL-4-OXO-2-BUTENOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-05-15 | — | — | WO | disclosed |