Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093027 | 0.92 | NAMPT (0.35) | NAMPTPIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8092862 | 0.87 | PIK3CD (0.40) | MAPTKDM4EPIK3CDPIK3CAMEN1 | |
| SCHEMBL8090246 | 0.86 | PIK3CA (0.42) | MAPTKDM4EHTTNAMPTCNR2 | |
| SCHEMBL8083986 | 0.85 | CA2 (0.39) | MAPTKDM4EHTTNAMPTPIK3CD | |
| SCHEMBL8091293 | 0.85 | MAPT (0.42) | MAPTKDM4EHTTNAMPTCNR2 | |
| SCHEMBL8100826 | 0.85 | NAMPT (0.40) | MAPTKDM4EHTTNAMPTPIK3CD | |
| SCHEMBL8084600 | 0.85 | PIK3CD (0.45) | MAPTKDM4EPIK3CDPIK3CAMEN1 | |
| SCHEMBL8089052 | 0.85 | CA2 (0.41) | MAPTKDM4EHTTNAMPTPIK3CD | |
| SCHEMBL8096233 | 0.84 | PIK3CD (0.40) | MAPTKDM4EHTTNAMPTPIK3CD | |
| SCHEMBL8097581 | 0.84 | MAPT (0.38) | MAPTKDM4EHTTNAMPTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |