Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097463 | 0.93 | PIK3CA (0.39) | MAPTKDM4EHTTCNR2ATR | |
| SCHEMBL8084155 | 0.91 | MAPT (0.39) | MAPTKDM4EHTTCNR2MEN1 | |
| SCHEMBL8090868 | 0.91 | MTOR (0.38) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8083200 | 0.90 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1KIF11CA1 | |
| SCHEMBL8090246 | 0.89 | PIK3CA (0.42) | MAPTKDM4EHTTCNR2MEN1 | |
| SCHEMBL8097966 | 0.88 | KIF11 (0.37) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8085029 | 0.87 | KIF11 (0.38) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8106295 | 0.86 | CA12 (0.42) | MAPTKDM4EHTTCNR2MEN1 | |
| SCHEMBL8083416 | 0.86 | PIK3R1 (0.39) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8084982 | 0.86 | KIF11 (0.38) | HTTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |