Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR2 | Q969V1 | 8/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.37 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7632592 | 0.87 | MCHR2 (0.53) | MCHR2DRD2SLC6A4TRPV1KCNH2 | |
| SCHEMBL12084760 | 0.87 | MCHR2 (0.53) | MCHR2DRD2SLC6A4TRPV1KCNH2 | |
| SCHEMBL12316034 | 0.84 | KMT2A (0.43) | MCHR2DRD2SLC6A4TRPV1KCNH2 | |
| SCHEMBL14530304 | 0.82 | HTT (0.47) | MCHR2DRD2SLC6A4LMNA | |
| SCHEMBL9089853 | 0.81 | HSD11B1 (0.46) | MCHR2DRD2SLC6A4TRPV1KCNH2 | |
| SCHEMBL12084784 | 0.81 | OPRM1 (0.43) | MCHR2DRD2SLC6A4KCNH2NAE1 | |
| SCHEMBL652661 | 0.81 | OPRM1 (0.43) | MCHR2DRD2SLC6A4KCNH2NAE1 | |
| SCHEMBL651529 | 0.79 | HSD11B1 (0.40) | MCHR2KCNH2LMNANAE1UBA3 | |
| SCHEMBL240533 | 0.77 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2SIGMAR1 | |
| SCHEMBL240532 | 0.77 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013644-A | AIDS THERAPY | MERCK & CO., INC. (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0681571-B1 | SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-07-29 | — | — | EP | disclosed |
| WO-1998025604-A1 | SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0681571-A1 | SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017045-A1 | SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-08-04 | — | — | WO | disclosed |