Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095856 | 0.99 | ALDH1A1 (0.43) | PTGS2PTGS1ALDH1A1LMNADPP4 | |
| SCHEMBL8094759 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1ALDH1A1LMNA | |
| SCHEMBL8099590 | 0.90 | PTGS2 (0.54) | PTGS2PTGS1ALDH1A1LMNA | |
| SCHEMBL8776719 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1ALDH1A1LMNACNR1 | |
| SCHEMBL8094910 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL8094996 | 0.83 | PTGS2 (0.48) | PTGS2PTGS1DPP4CA12CA1 | |
| SCHEMBL8094384 | 0.82 | MAPK13 (0.47) | PTGS2PTGS1ALDH1A1LMNACA12 | |
| SCHEMBL8101167 | 0.82 | PTGS2 (0.45) | PTGS2PTGS1CNR1CNR2IKBKB | |
| SCHEMBL8093245 | 0.81 | ALDH1A1 (0.45) | PTGS2PTGS1ALDH1A1LMNACA12 | |
| SCHEMBL8098730 | 0.80 | CNR1 (0.44) | PTGS2PTGS1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |