Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 13/20 | 0.52 |
| ▸ | CA1 | P00915 | 13/20 | 0.52 |
| ▸ | CA2 | P00918 | 12/20 | 0.52 |
| ▸ | CA4 | P22748 | 10/20 | 0.52 |
| ▸ | CA5A | P35218 | 10/20 | 0.52 |
| ▸ | CA7 | P43166 | 10/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 10/20 | 0.52 |
| ▸ | CA9 | Q16790 | 7/20 | 0.52 |
| ▸ | CA6 | P23280 | 4/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.52 |
| ▸ | P4HB | P07237 | 2/20 | 0.50 |
| ▸ | PDIA4 | P13667 | 1/20 | 0.50 |
| ▸ | PDIA3 | P30101 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108900 | 0.93 | TSHR (0.54) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL4368202 | 0.88 | TSHR (0.64) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL8109770 | 0.83 | TSHR (0.60) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL1726710 | 0.82 | P4HB (0.61) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL8654501 | 0.82 | P4HB (0.61) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL8109660 | 0.81 | TSHR (0.58) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL4371658 | 0.80 | TSHR (0.70) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL9007978 | 0.80 | TSHR (0.69) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL9007982 | 0.80 | TSHR (0.69) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL5273793 | 0.79 | TSHR (0.61) | TSHRPTPN1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6305971-A | — | — | None | — | — | JP | disclosed |
| EP-0598359-B1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO (JP) | 2000-06-14 | — | — | EP | disclosed |
| US-5731292-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| US-5424406-A | Useful in treatment of diabetes | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| JP-H06305971-A | HYPOGLYCEMIC AGENT | TANABE SEIYAKU CO LTD | 1994-11-01 | — | — | JP | disclosed |
| EP-0598359-A1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1994-05-25 | — | — | EP | disclosed |