Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA4 | P22748 | 4/20 | 0.43 |
| ▸ | CA5A | P35218 | 4/20 | 0.43 |
| ▸ | CA7 | P43166 | 4/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109660 | 0.84 | TSHR (0.58) | TSHRLMNAPTPN1KMT2AALDH1A1 | |
| SCHEMBL8101493 | 0.83 | TSHR (0.61) | TSHRPTPN1CA12CA1CA2 | |
| SCHEMBL12731192 | 0.79 | TSHR (0.76) | TSHRLMNAPTPN1KMT2AALDH1A1 | |
| SCHEMBL5272525 | 0.78 | SLC5A2 (0.61) | TSHRLMNAPTPN1KMT2AALDH1A1 | |
| SCHEMBL7256752 | 0.77 | TSHR (0.66) | TSHRLMNAPTPN1ALDH1A1CYP2D6 | |
| SCHEMBL7260809 | 0.77 | TSHR (0.66) | TSHRLMNAPTPN1ALDH1A1CYP2D6 | |
| SCHEMBL7256862 | 0.77 | TSHR (0.66) | TSHRLMNAPTPN1ALDH1A1CYP2D6 | |
| SCHEMBL9007982 | 0.77 | TSHR (0.69) | TSHRLMNAPTPN1KMT2ACYP2D6 | |
| SCHEMBL9007978 | 0.77 | TSHR (0.69) | TSHRLMNAPTPN1KMT2ACYP2D6 | |
| SCHEMBL8108900 | 0.77 | TSHR (0.54) | TSHRPTPN1CYP2D6CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598359-B1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO (JP) | 2000-06-14 | — | — | EP | disclosed |
| US-5731292-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| US-5424406-A | Useful in treatment of diabetes | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| EP-0598359-A1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1994-05-25 | — | — | EP | disclosed |