Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | P4HB | P07237 | 1/20 | 0.52 |
| ▸ | PDIA4 | P13667 | 1/20 | 0.52 |
| ▸ | PDIA3 | P30101 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 12/20 | 0.49 |
| ▸ | CA1 | P00915 | 12/20 | 0.49 |
| ▸ | CA2 | P00918 | 12/20 | 0.49 |
| ▸ | CA9 | Q16790 | 12/20 | 0.49 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101493 | 0.93 | TSHR (0.61) | TSHRP4HBPDIA4PDIA3CA12 | |
| SCHEMBL8376183 | 0.87 | P4HB (0.57) | TSHRP4HBPDIA4PDIA3PRKCA | |
| SCHEMBL8376188 | 0.87 | P4HB (0.57) | TSHRP4HBPDIA4PDIA3PRKCA | |
| SCHEMBL1726710 | 0.82 | P4HB (0.61) | TSHRP4HBPDIA4PDIA3CA12 | |
| SCHEMBL8654501 | 0.82 | P4HB (0.61) | TSHRP4HBPDIA4PDIA3CA12 | |
| SCHEMBL4368202 | 0.82 | TSHR (0.64) | TSHRP4HBPDIA4PDIA3CA12 | |
| SCHEMBL12651652 | 0.81 | P4HB (0.59) | TSHRP4HBPDIA4PDIA3PRKCA | |
| SCHEMBL12651802 | 0.81 | P4HB (0.59) | TSHRP4HBPDIA4PDIA3PRKCA | |
| SCHEMBL8109770 | 0.77 | TSHR (0.60) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL11154076 | 0.77 | MEN1 (0.56) | TSHRP4HBPDIA4PDIA3PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598359-B1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO (JP) | 2000-06-14 | — | — | EP | disclosed |
| EP-0684254-B1 | Propiophenone derivative and a process for preparing the same | TANABE SEIYAKU CO (JP) | 1999-03-24 | — | — | EP | disclosed |
| US-5830873-A | ANTIDIABETIC AGENT | TANABE SEIYAKU CO., LTD. (JP) | 1998-11-03 | — | — | US | disclosed |
| US-5731292-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| EP-0684254-A1 | Propiophenone derivative and a process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-11-29 | — | — | EP | disclosed |
| US-5424406-A | Useful in treatment of diabetes | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| EP-0598359-A1 | Hypoglycemic dihydrochalcone derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1994-05-25 | — | — | EP | disclosed |