Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31272173 | 0.75 | PDE7A (0.78) | LMNASMN1; SMN2PDE7AALDH1A1MAPT | |
| SCHEMBL875772 | 0.75 | PDE7A (0.78) | LMNASMN1; SMN2PDE7AALDH1A1MAPT | |
| SCHEMBL8101641 | 0.73 | PKM (0.47) | LMNAALDH1A1HTTPOLBMAPT | |
| SCHEMBL2417324 | 0.73 | PDE7A (0.64) | LMNASMN1; SMN2PDE7AALDH1A1HTT | |
| SCHEMBL6746930 | 0.72 | MAPK8 (0.69) | LMNASMN1; SMN2ALDH1A1HTTPOLB | |
| SCHEMBL1208099 | 0.71 | MGAM (0.68) | LMNASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL8881808 | 0.70 | MAPT (0.58) | LMNASMN1; SMN2PDE7AALDH1A1HTT | |
| SCHEMBL7114205 | 0.70 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2PDE7AALDH1A1HTT | |
| SCHEMBL3384869 | 0.69 | PDE7A (0.58) | LMNASMN1; SMN2PDE7AALDH1A1MAPT | |
| SCHEMBL1341344 | 0.69 | PDE7A (0.54) | LMNASMN1; SMN2PDE7AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |