SCHEMBL8101802

SCHEMBL8101802

[c]1nc2c(-c3cnccn3)cccc2s1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 2/20 0.34
ADRA1B P35368 2/20 0.34
METAP2 P50579 1/20 0.34
ALOX5AP P20292 2/20 0.33
FEN1 P39748 2/20 0.33
ADRA1D P25100 1/20 0.33
PIM2 Q9P1W9 1/20 0.33
DCTPP1 Q9H773 1/20 0.32
KDR P35968 1/20 0.32
PIK3CD O00329 1/20 0.31
PIK3CA P42336 1/20 0.31
PIK3CB P42338 1/20 0.31
PI4KA P42356 1/20 0.31
PIK3CG P48736 1/20 0.31
PI4KB Q9UBF8 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
CASP6 P55212 1/20 0.31
PIM1 P11309 2/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9837227 0.81 KDM4E (0.41) KDM4EALDH1A1POLBHPGDHSD17B10
SCHEMBL10411212 0.78
SCHEMBL7446653 0.76 RECQL (0.35) KDM4EALDH1A1POLBHPGDNR4A1
SCHEMBL21351983 0.76
SCHEMBL16150637 0.74 NOTUM (0.38) PIK3CDPIK3CAPIM1KDM4EALDH1A1
SCHEMBL7236507 0.74 NPC1 (0.41) ADORA2AADORA1KDM4EALDH1A1HPGD
SCHEMBL6487723 0.73 LIMK1 (0.30)
SCHEMBL4337978 0.72 LIMK1 (0.39) METAP2KDRALDH1A1HPGDHSD17B10
SCHEMBL17557843 0.71 KDM4E (0.32) KDM4E
SCHEMBL4190824 0.71 PDPK1 (0.43) ADRA1AADRA1BADRA1DADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785923-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-04-05 EP claimed