⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487723 | 0.86 | LIMK1 (0.30) | — | |
| SCHEMBL10411212 | 0.85 | — | — | |
| SCHEMBL9837227 | 0.81 | KDM4E (0.41) | — | |
| SCHEMBL8942364 | 0.79 | ADORA2A (0.32) | — | |
| SCHEMBL4337978 | 0.78 | LIMK1 (0.39) | — | |
| SCHEMBL16150637 | 0.77 | NOTUM (0.38) | — | |
| SCHEMBL8101802 | 0.76 | ADRA1A (0.34) | — | |
| SCHEMBL6222047 | 0.76 | HPGDS (0.36) | — | |
| SCHEMBL7449763 | 0.74 | CLK4 (0.33) | — | |
| SCHEMBL11200488 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745389-B2 | HDAC6 selective inhibitors, preparation method therefor, and application thereof | CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. (CN) | 2020-08-18 | — | — | US | disclosed |
| EP-3569592-A1 | HDAC6 SELECTIVE INHIBITORS, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD. (CN) | 2019-11-20 | — | — | EP | disclosed |
| US-20190284192-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD. (CN) | 2019-09-19 | — | — | US | disclosed |
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |