Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32688213 | 0.85 | GRIN1 (0.48) | GRIN1GRIN2APARP1PKMKDM4E | |
| SCHEMBL8092506 | 0.82 | ALDH1A1 (0.55) | PARP1PKMKDM4EALDH1A1HPGD | |
| SCHEMBL8102203 | 0.81 | HSP90AA1 (0.47) | PARP1PKMKDM4EALDH1A1HPGD | |
| SCHEMBL7920187 | 0.81 | DCTPP1 (0.48) | GRIN1GRIN2APKMKDM4EALDH1A1 | |
| SCHEMBL32688343 | 0.81 | DCTPP1 (0.48) | GRIN1GRIN2APKMKDM4EALDH1A1 | |
| SCHEMBL32688219 | 0.80 | GRIN1 (0.44) | GRIN1GRIN2APARP1PKMKDM4E | |
| SCHEMBL1660663 | 0.79 | NPC1 (0.56) | GRIN1GRIN2APKMKDM4EALDH1A1 | |
| SCHEMBL28615697 | 0.77 | NPC1 (0.58) | PKMKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8099857 | 0.77 | NR1H4 (0.50) | GRIN1GRIN2APARP1PKMKDM4E | |
| SCHEMBL8099803 | 0.77 | NPC1 (0.51) | GRIN1GRIN2APKMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |