Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32688343 | 1.00 | DCTPP1 (0.48) | DCTPP1POLBMAPTALDH1A1KDM4E | |
| SCHEMBL32688213 | 0.84 | GRIN1 (0.48) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL7920089 | 0.83 | HSP90AA1 (0.49) | DCTPP1POLBMAPTALDH1A1KDM4E | |
| SCHEMBL7920470 | 0.82 | KDM4E (0.54) | DCTPP1POLBMAPTALDH1A1KDM4E | |
| SCHEMBL8101985 | 0.81 | GRIN1 (0.46) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL32688219 | 0.79 | GRIN1 (0.44) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL1660663 | 0.78 | NPC1 (0.56) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL7920472 | 0.77 | DCTPP1 (0.48) | DCTPP1POLBMAPTALDH1A1KDM4E | |
| SCHEMBL19819254 | 0.77 | ALDH1A1 (0.68) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL8092481 | 0.76 | ALDH1A3 (0.52) | MAPTALDH1A1KDM4EHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6229016-B1 | PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-05-08 | — | — | US | disclosed |
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |