SCHEMBL8102261

SCHEMBL8102261

COC(=O)c1ccc2cc(OC(=O)NCc3cccnc3)ccc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.59
GAA P10253 1/20 0.58
CYP19A1 P11511 1/20 0.56
CYP11B1 P15538 1/20 0.56
CYP11B2 P19099 1/20 0.56
POLB P06746 1/20 0.55
HPGD P15428 1/20 0.55
LMNA P02545 1/20 0.53
MAPK1 P28482 1/20 0.53
ALDH1A1 P00352 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
MMP13 P45452 1/20 0.52
USP2 O75604 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TSHR P16473 2/20 0.51
NAMPT P43490 3/20 0.51
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
EGFR P00533 1/20 0.50
THRB P10828 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8100690 0.89 EPHX1 (0.65) EPHX1GAAPOLBHPGDLMNA
Hydrochloric Acid SCHEMBL10631732 0.78 CYP19A1 (0.62) GAACYP19A1CYP11B1CYP11B2ALDH1A1
SCHEMBL2412756 0.77 HDAC1 (0.67) EPHX1GAAHPGDALDH1A1TSHR
SCHEMBL29881595 0.77 EPHX1 (0.79) EPHX1HPGDLMNAUSP2NAMPT
SCHEMBL3430736 0.77 EPHX1 (0.79) EPHX1HPGDLMNAUSP2NAMPT
SCHEMBL13955307 0.76 RECQL (0.66) EPHX1GAAHPGDALDH1A1L3MBTL1
SCHEMBL4189515 0.74 EPHX1 (1.00) EPHX1LMNANAMPTSMN1; SMN2
SCHEMBL5166793 0.74 CYP1A2 (0.87) GAAPOLBHPGDMAPK1ALDH1A1
SCHEMBL8326064 0.73 GAA (1.00) GAAPOLBHPGDLMNAMAPK1
SCHEMBL10692778 0.73 CYP19A1 (0.69) GAACYP19A1CYP11B1CYP11B2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013674-A INDENONE AMIDE DERIVATIVES, USEFUL FOR FOR THE INHIBITION OF LEUKOCYTE ADHERENCE TO ENDOTHELIAL CELLS; USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, AS ARTHRITIS, ASTHAMA, PSORIASIS, RESPIRATORY DISTRESS SYNDROME, STROKE AND ULCER ELI LILLY AND COMPANY (US) 2000-01-11 US disclosed
EP-0882706-A1 Cell adhesion inhibitors ELI LILLY AND COMPANY (US) 1998-12-09 EP disclosed