Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102261 | 0.89 | EPHX1 (0.59) | EPHX1GAAPOLBHPGDNAMPT | |
| SCHEMBL29881595 | 0.81 | EPHX1 (0.79) | EPHX1HPGDNAMPTLMNAFAAH | |
| SCHEMBL3430736 | 0.81 | EPHX1 (0.79) | EPHX1HPGDNAMPTLMNAFAAH | |
| SCHEMBL4189515 | 0.79 | EPHX1 (1.00) | EPHX1NAMPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL27687099 | 0.76 | EPHX1 (0.70) | EPHX1GAAHPGDNAMPTLMNA | |
| SCHEMBL2410964 | 0.76 | HDAC1 (0.70) | EPHX1NAMPTHTTSMN1; SMN2 | |
| SCHEMBL31323132 | 0.76 | NPC1 (0.59) | EPHX1FAAHALDH1A1 | |
| SCHEMBL14470496 | 0.76 | NPC1 (0.59) | EPHX1FAAHALDH1A1 | |
| SCHEMBL10627493 | 0.75 | TBXAS1 (0.54) | GAAALDH1A1 | |
| SCHEMBL6944020 | 0.75 | PKM (0.66) | GAAHPGDNAMPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810206-B1 | Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| EP-0810206-A1 | Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-03 | — | — | EP | disclosed |