Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.79 |
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881595 | 1.00 | EPHX1 (0.79) | EPHX1NAMPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27687099 | 0.91 | EPHX1 (0.70) | EPHX1NAMPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4189515 | 0.88 | EPHX1 (1.00) | EPHX1NAMPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL5108159 | 0.84 | NPC1 (0.69) | EPHX1RECQLHTTHPGD | |
| SCHEMBL590484 | 0.83 | EPHX1 (0.77) | EPHX1CYP3A4FAAHLMNAHTT | |
| SCHEMBL1568902 | 0.83 | NAMPT (0.65) | EPHX1NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2861622 | 0.83 | EPHX1 (0.60) | EPHX1NAMPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7742679 | 0.82 | NAMPT (0.68) | EPHX1NAMPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13955307 | 0.81 | RECQL (0.66) | EPHX1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8100690 | 0.81 | EPHX1 (0.65) | EPHX1NAMPTRECQLFAAHUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-11-07 | — | — | US | disclosed |
| WO-2020158841-A1 | HYDRAZIDE COMPOUND AND KINASE INHIBITOR | 日産化学株式会社 | 2020-08-06 | — | — | WO | disclosed |
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |
| WO-2014111871-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-07-24 | — | — | WO | disclosed |
| WO-2012002502-A1 | DIHYDROPYRIMIDINONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 大日本住友製薬株式会社 (JP) | 2012-01-05 | — | — | WO | disclosed |
| US-20100298366-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| US-7790747-B2 | Chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1942890-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORP (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20090099205-A1 | Chemokine receptor binding compounds | GENZYME CORPORATION | 2009-04-16 | — | — | US | disclosed |
| EP-1942890-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2008-07-16 | — | — | EP | disclosed |
| WO-2006138350-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-12-28 | — | — | WO | disclosed |
| US-4172893-A | Rodenticidal 3-pyridylmethyl phenyl carbamate metal salt complexes | ROHM AND HAAS COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4075345-A | 3-PYRIDYLMETHYL ARYL UREA RODENTICIDES COMPOSITIONS | ROHM AND HAAS COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-3994905-A | 3-Pyridylmethyl aryl urea rodenticides | ROHM AND HAAS COMPANY (US) | 1976-11-30 | — | — | US | disclosed |
| US-3931203-A | 3-Pyridylmethyl aryl urea rodenticides | ROHM AND HAAS COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298366-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | CCR5, CXCR3, CCL5 | EPHX1 1384/4885NAMPT 1243/4885CYP1A2 4376/4885 |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | EPHX1 3475/4885NAMPT 1/4885CYP1A2 3759/4885 |
| US-20090099205-A1 | Chemokine receptor binding compounds | CCR5, CXCR3, CCL5 | EPHX1 1384/4885NAMPT 1243/4885CYP1A2 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.