Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.43 |
| ▸ | RXRB | P28702 | 9/20 | 0.43 |
| ▸ | RXRG | P48443 | 9/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.39 |
| ▸ | RARB | P10826 | 7/20 | 0.36 |
| ▸ | RARG | P13631 | 7/20 | 0.36 |
| ▸ | RARA | P10276 | 6/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876781 | 0.90 | RXRA (0.44) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL7876780 | 0.88 | RXRA (0.41) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839361 | 0.85 | RXRA (0.48) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8092911 | 0.84 | RXRA (0.55) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839144 | 0.83 | RXRA (0.47) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8100803 | 0.83 | RXRA (0.44) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839151 | 0.82 | RXRA (0.46) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8100597 | 0.81 | RXRA (0.44) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8106667 | 0.79 | RXRA (0.38) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839195 | 0.78 | CYP3A4 (0.52) | RXRARXRBRXRGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |