Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.38 |
| ▸ | RXRB | P28702 | 9/20 | 0.38 |
| ▸ | RXRG | P48443 | 9/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876781 | 0.88 | RXRA (0.44) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8102470 | 0.79 | RXRA (0.43) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8457027 | 0.75 | CYP3A4 (0.39) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL7876780 | 0.74 | RXRA (0.41) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839361 | 0.74 | RXRA (0.48) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8457429 | 0.73 | RARA (0.56) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8457030 | 0.73 | RXRA (0.41) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839144 | 0.73 | RXRA (0.47) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8839178 | 0.72 | CYP3A4 (0.58) | RXRARXRBRXRGCYP3A4CYP26A1 | |
| SCHEMBL8106662 | 0.72 | RARA (0.43) | RXRARXRBRXRGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |