SCHEMBL8094793

SCHEMBL8094793

CSC1CC(=O)N1CC(=O)O

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.37
TSHR P16473 2/20 0.35
SIGMAR1 Q99720 1/20 0.35
ACE P12821 3/20 0.33
MEN1 O00255 1/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
KMT2A Q03164 1/20 0.33
APEX1 P27695 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
ITGB1 P05556 1/20 0.31
ITGA5 P08648 1/20 0.31
HTT P42858 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
MDM2 Q00987 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9638907 0.81 L3MBTL1 (0.35) L3MBTL1TSHRSIGMAR1ACEMEN1
SCHEMBL11454413 0.80 ALDH1A1 (0.38) L3MBTL1TSHRSIGMAR1MEN1GSK3A
SCHEMBL8104132 0.79 ALDH1A1 (0.43) L3MBTL1SIGMAR1MEN1GSK3AGSK3B
SCHEMBL11454284 0.77 BRD4 (0.38) SMN1; SMN2
SCHEMBL8439418 0.76 SIGMAR1 (0.40) L3MBTL1TSHRSIGMAR1KMT2AAPEX1
SCHEMBL11460980 0.76 L3MBTL1 (0.49) L3MBTL1TSHRMEN1KMT2ASMN1; SMN2
SCHEMBL11452523 0.75 GAA (0.39) MEN1GSK3AGSK3BKMT2AALDH1A1
SCHEMBL11106025 0.74 ALDH1A1 (0.44) L3MBTL1TSHRSMN1; SMN2ALDH1A1
SCHEMBL8104160 0.73 HDAC3 (0.42) MEN1KMT2ASMN1; SMN2
SCHEMBL8441054 0.73 PDPK1 (0.49) KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788478-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1997-08-13 EP claimed
WO-1996013484-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1996-05-09 WO claimed
US-6071899-A Azetidinone derivatives for the treatment of atherosclerosis SMITHKLINE BEECHAM P.L.C. (GB) 2000-06-06 US disclosed
US-6071899-A Azetidinone derivatives for the treatment of atherosclerosis SMITHKLINE BEECHAM P.L.C. (GB) 2000-06-06 US disclosed
EP-0788478-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1997-08-13 EP disclosed
EP-0788478-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1997-08-13 EP disclosed
WO-1996013484-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1996-05-09 WO disclosed
WO-1996013484-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1996-05-09 WO disclosed
US-4639441-A ANTIBACTERIAL PENICILLINS SANKYO COMPANY LIMITED (JP) 1987-01-27 US disclosed
US-4206120-A Oxaazabicycloheptane antibiotics BEECHAM GROUP LIMITED (GB) 1980-06-03 US disclosed