Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | RARB | P10826 | 9/20 | 0.44 |
| ▸ | RARA | P10276 | 8/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.44 |
| ▸ | RARG | P13631 | 6/20 | 0.43 |
| ▸ | RXRA | P19793 | 7/20 | 0.43 |
| ▸ | RXRB | P28702 | 7/20 | 0.43 |
| ▸ | RXRG | P48443 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879903 | 0.86 | RXRA (0.44) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL7887936 | 0.83 | CYP26A1 (0.52) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL8458134 | 0.81 | CYP26A1 (0.65) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL8839222 | 0.81 | RXRA (0.50) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL5084209 | 0.80 | RXRA (0.66) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL9255914 | 0.79 | RXRA (0.48) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL7880475 | 0.79 | CYP3A4 (0.40) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL8457437 | 0.78 | CYP3A4 (0.43) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL8459684 | 0.78 | CYP3A4 (0.43) | CYP3A4RARBRARACYP26A1CYP26B1 | |
| SCHEMBL8839100 | 0.78 | RXRA (0.45) | CYP3A4RARBRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |