Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.60 |
| ▸ | HTR2B | P41595 | 16/20 | 0.60 |
| ▸ | HTR2A | P28223 | 15/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102751 | 1.00 | HTR2C (0.60) | HTR2CHTR2BHTR2ADPP4 | |
| SCHEMBL6857793 | 0.83 | HTR2C (0.64) | HTR2CHTR2BHTR2A | |
| SCHEMBL17962683 | 0.75 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL8097737 | 0.74 | FFAR1 (0.52) | — | |
| SCHEMBL8097739 | 0.74 | FFAR1 (0.52) | — | |
| SCHEMBL28635476 | 0.73 | HTR2C (0.78) | HTR2CHTR2BHTR2A | |
| SCHEMBL8097678 | 0.72 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL15255093 | 0.72 | HTR2C (0.64) | HTR2CHTR2BHTR2A | |
| SCHEMBL8097675 | 0.72 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL15255094 | 0.72 | HTR2C (1.00) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |