Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763669 | 0.87 | APP (0.48) | CFTRGAAKDM4ENOTUMPOLB | |
| SCHEMBL168616 | 0.87 | CFTR (0.47) | CFTRGAAKDM4ENOTUMKMT2A | |
| SCHEMBL1763923 | 0.85 | CFTR (0.41) | CFTRGAAKDM4ENOTUMKMT2A | |
| SCHEMBL22987095 | 0.85 | GAA (0.60) | CFTRGAAKDM4ENOTUMPOLB | |
| SCHEMBL8333315 | 0.85 | GAA (0.49) | CFTRGAAKDM4ENOTUMKMT2A | |
| SCHEMBL21822936 | 0.85 | NOTUM (0.55) | CFTRGAAKDM4ENOTUMKMT2A | |
| SCHEMBL5874056 | 0.84 | ALDH1A1 (0.50) | KDM4EHTR2AHTR2CALDH1A1HPGD | |
| SCHEMBL24515867 | 0.83 | APP (0.48) | CFTRGAAKDM4ENOTUMPOLB | |
| SCHEMBL7800039 | 0.83 | S1PR1 (0.47) | CFTRGAAKDM4ENOTUMPOLB | |
| SCHEMBL31603104 | 0.82 | CFTR (0.68) | CFTRGAAKDM4ENOTUMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153651-A | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-11-28 | — | — | US | disclosed |