Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | CFTR | P13569 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22987089 | 0.86 | ALDH1A1 (0.50) | GAAKDM4ECFTRALDH1A1HSD17B10 | |
| SCHEMBL8102763 | 0.85 | CFTR (0.49) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL1763669 | 0.83 | APP (0.48) | GAAKDM4ECFTRPOLBALDH1A1 | |
| SCHEMBL168616 | 0.83 | CFTR (0.47) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL6473999 | 0.81 | GAA (0.74) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL29424850 | 0.81 | GAA (0.74) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL31603104 | 0.81 | CFTR (0.68) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL21822936 | 0.81 | NOTUM (0.55) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL2031824 | 0.81 | CFTR (0.60) | GAAKDM4ECFTRPOLBMAPT | |
| SCHEMBL11568484 | 0.80 | KDM4E (0.76) | GAAKDM4ECFTRPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3586838-B1 | AMIDE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3586838-B1 | AMIDE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| US-10925848-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-02-23 | — | — | US | disclosed |
| US-10925848-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10925848-B2 | Amide derivative | IDO1, IDO2, TPH1 | GAA 1221/4885KDM4E 2941/4885CFTR 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.