Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128132 | 0.83 | MAPK14 (0.50) | MAPK14HSD17B10ALDH1A1MAPK13MAPK12 | |
| SCHEMBL8102854 | 0.83 | MAPK14 (0.47) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL21466389 | 0.80 | FAAH (0.50) | MAPK14FAAHALDH1A1MAPK13MAPK12 | |
| SCHEMBL16573709 | 0.78 | MAPK14 (0.47) | MAPK14ALDH1A1MAPK13MAPK12MAPK11 | |
| SCHEMBL16573706 | 0.76 | MAPK14 (0.41) | MAPK14ALDH1A1MAPK13MAPK12MAPK11 | |
| SCHEMBL8098012 | 0.76 | MAPK14 (0.41) | MAPK14ALDH1A1MAPK13MAPK12MAPK11 | |
| SCHEMBL7144420 | 0.73 | MAPK14 (0.58) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL5903491 | 0.71 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7144416 | 0.71 | MAPK14 (0.75) | MAPK14FAAHMAPK13MAPK12MAPK11 | |
| SCHEMBL7162537 | 0.71 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994858-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1999003837-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-01-28 | — | — | WO | claimed |