Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | GMPS | P49915 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8104687 | 0.86 | EGFR (0.70) | EGFRAURKBERBB2ERBB4HDAC6 | |
| SCHEMBL8104967 | 0.81 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL8110759 | 0.79 | EGFR (0.74) | EGFRERBB2ERBB4 | |
| SCHEMBL2248477 | 0.77 | EGFR (0.77) | EGFRAURKBERBB2ERBB4HDAC6 | |
| SCHEMBL27819297 | 0.77 | EGFR (0.74) | EGFRAURKBERBB2ERBB4HDAC6 | |
| SCHEMBL7763004 | 0.76 | ALK (0.60) | EGFRERBB2 | |
| SCHEMBL7766632 | 0.76 | EGFR (0.57) | EGFRERBB2ERBB4HDAC6HDAC1 | |
| SCHEMBL8310027 | 0.76 | EGFR (0.66) | EGFRAURKBERBB2ERBB4GMPS | |
| SCHEMBL2255586 | 0.75 | EGFR (0.74) | EGFRAURKBERBB2ERBB4HDAC6 | |
| SCHEMBL7760716 | 0.75 | EGFR (0.70) | EGFRAURKBERBB2ERBB4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |
| EP-0824526-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033978-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |