Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MYOC | Q99972 | 1/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943829 | 0.88 | RORC (0.52) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL6938062 | 0.86 | ABCG2 (0.59) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL8110807 | 0.84 | MEN1 (0.72) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL6943827 | 0.83 | ABCG2 (0.68) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL8109093 | 0.83 | MEN1 (0.78) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL11027238 | 0.82 | MEN1 (0.88) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL11832409 | 0.82 | MEN1 (0.88) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL11004478 | 0.82 | MEN1 (1.00) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL8104826 | 0.82 | KMT2A (0.78) | MEN1KMT2AMAPTNPSR1NPC1 | |
| SCHEMBL14862017 | 0.82 | RORC (0.54) | MEN1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | Slovakofarma, A.S. (SK) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032437-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA, A.S. (SK) | 1999-07-01 | — | — | WO | disclosed |