Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | MAX | P61244 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14862341 | 0.86 | RORC (0.54) | RORCALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL15938160 | 0.82 | ALDH1A1 (0.60) | RORCALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6938062 | 0.82 | ABCG2 (0.59) | RORCABCG2IGF1RALDH1A1MEN1 | |
| SCHEMBL8103149 | 0.82 | MEN1 (0.67) | RORCABCG2IGF1RALDH1A1MEN1 | |
| SCHEMBL14861647 | 0.81 | KMT2A (0.53) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL16470335 | 0.80 | KMT2A (0.68) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7373448 | 0.78 | RORC (0.66) | RORCABCG2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15527542 | 0.78 | KMT2A (0.66) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14862217 | 0.76 | KDM4E (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15937964 | 0.76 | TRPV4 (0.51) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745257-B2 | Phenyl-guanidine derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2017-08-29 | — | — | US | claimed |
| EP-2766342-B1 | PHENYL-GUANIDINE DERIVATIVES | UNIV NAC QUILMES (AR) | 2016-02-10 | — | — | EP | claimed |
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2014-08-14 | — | — | US | claimed |
| CN-103917520-A | Phenyl-guanidine derivatives | UNIV NAC QUILMES | 2014-07-09 | — | — | CN | claimed |
| US-9745257-B2 | Phenyl-guanidine derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2017-08-29 | — | — | US | disclosed |
| EP-2766342-B1 | PHENYL-GUANIDINE DERIVATIVES | UNIV NAC QUILMES (AR) | 2016-02-10 | — | — | EP | disclosed |
| EP-2766342-A1 | PHENYL-GUANIDINE DERIVATIVES | Universidad Nacional de Quilmes (AR) | 2014-08-20 | — | — | EP | disclosed |
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2014-08-14 | — | — | US | disclosed |
| CN-103917520-A | Phenyl-guanidine derivatives | UNIV NAC QUILMES | 2014-07-09 | — | — | CN | disclosed |
| WO-2013053726-A1 | PHENYL-GUANIDINE DERIVATIVES | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2013-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | RAPGEF3, ARHGDIA, G3BP1 | RORC 3650/4885ABCG2 2598/4885IGF1R 3448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.