Tyramine

Tyramine

SCHEMBL8103419

COc1ccc(CCN)cc1.NCCc1ccc(N)cc1.NCCc1ccc(O)cc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.72
MAOB P27338 3/20 0.66
CALM1 P0DP23 2/20 0.66
ALDH1A1 P00352 2/20 0.62
KDM4E B2RXH2 1/20 0.62
HTR1A P08908 1/20 0.62
ADRA2A P08913 1/20 0.62
SLC6A2 P23975 1/20 0.62
CYP2C19 P33261 1/20 0.62
HTR3A P46098 1/20 0.62
BACE1 P56817 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
TDP1 Q9NUW8 3/20 0.60
BLM P54132 1/20 0.60
KMT2A Q03164 1/20 0.60
MAPK1 P28482 1/20 0.55
CYP19A1 P11511 1/20 0.54
CYP3A4 P08684 1/20 0.53
NPC1 O15118 1/20 0.51
MAPT P10636 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyramine SCHEMBL8339170 0.95 TAAR1 (0.81) TAAR1MAOBCALM1ALDH1A1KDM4E
Tyramine SCHEMBL8418379 0.87 TAAR1 (0.68) TAAR1MAOBCALM1ALDH1A1KDM4E
SCHEMBL4634 0.85 TAAR1 (1.00) TAAR1MAOBCALM1KDM4E
SCHEMBL8746062 0.83 CYP19A1 (0.74) TAAR1MAOBCALM1ALDH1A1TDP1
Bromide SCHEMBL25228226 0.83 TAAR1 (0.95) TAAR1MAOBCALM1KDM4E
Iodide SCHEMBL29184237 0.83 TAAR1 (0.95) TAAR1MAOBCALM1KDM4E
SCHEMBL3414787 0.83 CALM1 (0.84) TAAR1CALM1CYP19A1NPC1MAPT
SCHEMBL9468301 0.83 TAAR1 (0.95) TAAR1MAOBCALM1CYP19A1
Hydrochloric Acid SCHEMBL4473880 0.83 TAAR1 (0.95) TAAR1MAOBCALM1ALDH1A1TDP1
Thyronamine SCHEMBL449823 0.80 TAAR1 (0.75) TAAR1MAOBCALM1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
EP-0946549-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1999-10-06 EP disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998027087-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-06-25 WO disclosed