Tyramine

Tyramine

SCHEMBL8339170

COc1ccc(CCN)cc1.NCCc1ccc(O)cc1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.81
MAOB P27338 3/20 0.72
CALM1 P0DP23 2/20 0.72
KDM4E B2RXH2 1/20 0.69
ALDH1A1 P00352 1/20 0.69
HTR1A P08908 1/20 0.69
ADRA2A P08913 1/20 0.69
SLC6A2 P23975 1/20 0.69
CYP2C19 P33261 1/20 0.69
HTR3A P46098 1/20 0.69
BACE1 P56817 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
BLM P54132 1/20 0.67
KMT2A Q03164 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
NPC1 O15118 1/20 0.55
MAPT P10636 1/20 0.55
RAB9A P51151 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
ESR2 Q92731 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyramine SCHEMBL8103419 0.95 TAAR1 (0.72) TAAR1MAOBCALM1KDM4EALDH1A1
Tyramine SCHEMBL8418379 0.92 TAAR1 (0.68) TAAR1MAOBCALM1KDM4EALDH1A1
SCHEMBL4634 0.90 TAAR1 (1.00) TAAR1MAOBCALM1KDM4EIDO1
SCHEMBL9468301 0.88 TAAR1 (0.95) TAAR1MAOBCALM1CYP19A1IDO1
Hydrochloric Acid SCHEMBL4473880 0.88 TAAR1 (0.95) TAAR1MAOBCALM1ALDH1A1TDP1
Bromide SCHEMBL25228226 0.88 TAAR1 (0.95) TAAR1MAOBCALM1KDM4EIDO1
Iodide SCHEMBL29184237 0.88 TAAR1 (0.95) TAAR1MAOBCALM1KDM4EIDO1
SCHEMBL3414787 0.88 CALM1 (0.84) TAAR1CALM1NPC1MAPTRAB9A
SCHEMBL4842037 0.84 MAOB (1.00) TAAR1MAOBCALM1
Thyronamine SCHEMBL449823 0.84 TAAR1 (0.75) TAAR1MAOBCALM1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999031506-A9 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS LILLY CO ELI (US) 1999-09-16 WO disclosed
WO-1999031507-A1 PEPTIDOMIMETIC TEMPLATE-BASED COMBINATORIAL LIBRARIES ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1999031506-A1 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1999002990-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED SUBSTITUTED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1999-01-21 WO disclosed