SCHEMBL8103667

SCHEMBL8103667

NCCc1cccc(Cl)c1.N[C@@H](Cc1ccccc1)C(=O)Nc1ccc2ccccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.47
TP53 P04637 1/20 0.47
TAAR1 Q96RJ0 1/20 0.46
CMA1 P23946 2/20 0.45
ROCK2 O75116 4/20 0.44
GRIK1 P39086 1/20 0.43
GRIK2 Q13002 1/20 0.43
BACE1 P56817 2/20 0.43
HDAC8 Q9BY41 1/20 0.43
KDM4E B2RXH2 2/20 0.42
POLB P06746 1/20 0.42
TRHDE Q9UKU6 1/20 0.42
MEN1 O00255 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
KMT2A Q03164 2/20 0.41
ROCK1 Q13464 1/20 0.41
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
AKT1 P31749 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5145729 0.85 BACE1 (0.54) MAPTROCK2BACE1HDAC8KDM4E
SCHEMBL1614525 0.85 BACE1 (0.54) MAPTROCK2BACE1HDAC8KDM4E
SCHEMBL28556648 0.82 MAPT (0.65) MAPTTP53BACE1HDAC8KDM4E
SCHEMBL28556649 0.82 MAPT (0.65) MAPTTP53BACE1HDAC8KDM4E
Aminobenzoic Acid SCHEMBL5668488 0.78 LNPEP (0.51) ROCK2BACE1HDAC8KDM4EMEN1
SCHEMBL4610411 0.77 BACE1 (0.57) MAPTBACE1HDAC8KDM4EPOLB
SCHEMBL21880195 0.75 ROCK2 (0.60) ROCK2BACE1HDAC8MEN1NPC1
SCHEMBL10176502 0.75 ROCK2 (0.60) ROCK2BACE1HDAC8MEN1NPC1
SCHEMBL6663334 0.75 ROCK2 (0.60) ROCK2BACE1HDAC8MEN1NPC1
SCHEMBL20353450 0.73 ROCK2 (0.69) ROCK2ROCK1AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
EP-0946549-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1999-10-06 EP disclosed
EP-0938676-A1 COMBINATORIAL PROCESS FOR PREPARING THIAZOLIDINONE LIBRARIES ELI LILLY AND COMPANY (US) 1999-09-01 EP disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998027087-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-06-25 WO disclosed
WO-1998021584-A1 COMBINATORIAL PROCESS FOR PREPARING THIAZOLIDINONE LIBRARIES ELI LILLY AND COMPANY (US) 1998-05-22 WO disclosed