Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145729 | 1.00 | BACE1 (0.54) | BACE1HDAC8MAPTRAB9ANPC1 | |
| SCHEMBL4610411 | 0.91 | BACE1 (0.57) | BACE1HDAC8MAPTRAB9AMEN1 | |
| Aminobenzoic Acid SCHEMBL5668488 | 0.89 | LNPEP (0.51) | BACE1HDAC8MEN1KMT2ACYP1A2 | |
| SCHEMBL20353450 | 0.86 | ROCK2 (0.69) | ROCK2ROCK1AKT1 | |
| SCHEMBL8103667 | 0.85 | MAPT (0.47) | BACE1HDAC8MAPTRAB9ANPC1 | |
| Trifluoroacetic Acid SCHEMBL29527153 | 0.85 | HDAC8 (0.47) | BACE1HDAC8RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30485178 | 0.84 | LTA4H (0.60) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL25266534 | 0.84 | MEN1 (0.55) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL4609213 | 0.84 | MEN1 (0.55) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL30427471 | 0.84 | MEN1 (0.55) | MAPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895482-A1 | HIV PROTEASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-07-22 | — | — | EP | claimed |
| WO-2014043019-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-03-20 | — | — | WO | claimed |
| EP-0642587-A4 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA. | UNIV MICHIGAN (US) | 1997-03-19 | — | — | EP | claimed |
| EP-0642587-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | THE UNIVERSITY OF MICHIGAN (US) | 1995-03-15 | — | — | EP | claimed |
| WO-1993024651-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | UNIVERSITY OF MICHIGAN (US) | 1993-12-09 | — | — | WO | claimed |
| US-5116735-A | Colorimetric assay, hydrolysis of chromogen | THE UNIVERSITY OF MICHIGAN (US) | 1992-05-26 | — | — | US | claimed |
| EP-0165905-B1 | DIAGNOSTIC ASSAY METHOD FOR THE DETECTION OF ORAL PATHOGENIC BACTERIA MIXTURES | THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1989-03-08 | — | — | EP | claimed |
| WO-2023088470-A1 | PROBIOTIC COMPOSITIONS FOR TREATMENT OF HAIR LOSS | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-05-25 | — | — | WO | disclosed |
| US-10172306-B2 | Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures | PHYTON HOLDINGS, LLC (US) | 2019-01-08 | — | — | US | disclosed |
| WO-2018191561-A1 | METHODS AND COMPOSITIONS FOR SPACIAL AND TEMPORAL MEASUREMENT OF CATALYTIC ACTIVITY | THE UNIVERSITY OF CHICAGO (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20180042194-A1 | PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES | PHYTON HOLDINGS, LLC (US) | 2018-02-15 | — | — | US | disclosed |
| EP-3270686-A1 | PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES | Phyton Holdings, LLC (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016150860-A1 | PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES | PHYTON BIOTECH GMBH (DE) | 2016-09-29 | — | — | WO | disclosed |
| WO-1997044476-A1 | ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES | PHYTON, INC. (US) | 1997-11-27 | — | — | WO | disclosed |
| EP-0794253-A2 | Aminopeptidase GX, and a method of hydrolyzing a protein with the same | Ajinomoto Co., Ltd. (JP) | 1997-09-10 | — | — | EP | disclosed |
| EP-0642587-A4 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA. | UNIV MICHIGAN (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0642587-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | THE UNIVERSITY OF MICHIGAN (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024651-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | UNIVERSITY OF MICHIGAN (US) | 1993-12-09 | — | — | WO | disclosed |
| EP-0165905-B1 | DIAGNOSTIC ASSAY METHOD FOR THE DETECTION OF ORAL PATHOGENIC BACTERIA MIXTURES | THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1989-03-08 | — | — | EP | disclosed |
| EP-0165905-A1 | Diagnostic assay method for the detection of oral pathogenic bacteria mixtures | THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1985-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172306-B2 | Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures | LANCL2, ELOVL3, NFATC1 | BACE1 4693/4885HDAC8 2660/4885MAPT 4203/4885 |
| US-20180042194-A1 | PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES | ELOVL3, LANCL2, ICOS | BACE1 4642/4885HDAC8 2735/4885MAPT 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.