SCHEMBL8103739

SCHEMBL8103739

CC(N)c1ccccc1.NCC(O)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.52
LMNA P02545 2/20 0.52
AOC3 Q16853 5/20 0.50
HIF1A Q16665 2/20 0.50
KDM4E B2RXH2 2/20 0.50
HTR3A P46098 1/20 0.50
ADRA2A P08913 1/20 0.50
ADRA2C P18825 1/20 0.50
TSHR P16473 1/20 0.50
NFKB1 P19838 1/20 0.50
ALOX15 P16050 1/20 0.48
APEX1 P27695 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ALDH1A1 P00352 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8339683 0.88 TAAR1 (0.56) TAAR1LMNAAOC3HIF1AKDM4E
SCHEMBL2021 0.87 TAAR1 (0.62) TAAR1LMNAAOC3HIF1AKDM4E
SCHEMBL147501 0.87 TAAR1 (0.62) TAAR1LMNAAOC3HIF1AKDM4E
SCHEMBL175554 0.87 TAAR1 (0.62) TAAR1LMNAAOC3HIF1AKDM4E
N-Benzylmethylamine SCHEMBL8418277 0.86 KDM4E (0.49) TAAR1LMNAAOC3HIF1AKDM4E
Bromide SCHEMBL29131747 0.85 TAAR1 (0.60) TAAR1LMNAAOC3HIF1AKDM4E
Hydrochloric Acid SCHEMBL7153880 0.85 KDM4E (0.64) TAAR1LMNAAOC3HIF1AKDM4E
Hydrochloric Acid SCHEMBL29175850 0.85 KDM4E (0.64) TAAR1LMNAAOC3HIF1AKDM4E
Ammonia Solution, Strong SCHEMBL27544022 0.85 TAAR1 (0.60) TAAR1LMNAAOC3HIF1AKDM4E
Hydrochloric Acid SCHEMBL8178381 0.85 KDM4E (0.64) TAAR1LMNAAOC3HIF1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
WO-1999031506-A9 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS LILLY CO ELI (US) 1999-09-16 WO disclosed
WO-1999031506-A1 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1999031507-A1 PEPTIDOMIMETIC TEMPLATE-BASED COMBINATORIAL LIBRARIES ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed