SCHEMBL8103751

SCHEMBL8103751

O=C1CSCN1c1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.55

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.55
AR P10275 1/20 0.45
NOTUM Q6P988 17/20 0.43
KCNN4 O15554 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8099362 0.84 AR (0.52) MAPTARNOTUM
SCHEMBL8089677 0.82 MAPT (0.64) MAPT
SCHEMBL8103236 0.78 NOTUM (0.43) ARNOTUM
SCHEMBL8082058 0.78 MAPT (0.59) MAPTNOTUM
SCHEMBL8098719 0.78 MAPT (0.59) MAPT
SCHEMBL8098928 0.75 MAPT (0.44) MAPT
SCHEMBL8099209 0.75 MAPT (0.55) MAPT
SCHEMBL8098716 0.74 NOTUM (0.45) ARNOTUM
SCHEMBL4786129 0.74 MAPT (0.55) MAPT
SCHEMBL8105974 0.74 MEN1 (0.49) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0672038-B1 HERBICIDES ZENECA LTD (GB) 2000-01-19 EP disclosed
US-5856273-A CONTROLLING WEEDS ZENECA LIMITED (GB) 1999-01-05 US disclosed
EP-0672038-A1 HERBICIDES ZENECA LIMITED (GB) 1995-09-20 EP disclosed
WO-1994013652-A1 HERBICIDES ZENECA LIMITED (GB) 1994-06-23 WO disclosed