Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13103800 | 0.83 | NOTUM (0.42) | NOTUMBRD4NPC1RAB9ARXFP1 | |
| SCHEMBL4287576 | 0.80 | GPR84 (0.40) | NOTUMBRD4CA12CA1CA2 | |
| SCHEMBL10202698 | 0.78 | LMNA (0.41) | NOTUMBRD4NPC1RAB9ACA12 | |
| SCHEMBL14817732 | 0.78 | SPHK2 (0.41) | NOTUMBRD4NPC1RAB9ARXFP1 | |
| SCHEMBL13393578 | 0.75 | NPC1 (0.55) | NOTUMBRD4NPC1RAB9ARXFP1 | |
| SCHEMBL18567895 | 0.73 | NOTUM (0.46) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL16573949 | 0.72 | NOTUM (0.45) | NOTUMBRD4NPC1RAB9ARXFP1 | |
| SCHEMBL26206906 | 0.72 | NOTUM (0.45) | NOTUMBRD4NPC1RAB9ACA12 | |
| SCHEMBL8126280 | 0.72 | NPC1 (0.48) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13844166 | 0.71 | CA12 (0.40) | NOTUMBRD4NPC1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |