Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.55 |
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | DRD4 | P21917 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103863 | 1.00 | DRD3 (0.55) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7411424 | 0.84 | DRD2 (0.70) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7411429 | 0.84 | DRD2 (0.70) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL6931453 | 0.79 | DRD2 (0.67) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL17446285 | 0.78 | DRD2 (0.72) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL28183785 | 0.77 | DRD3 (0.63) | DRD3DRD2HTR1AFYN | |
| SCHEMBL6334883 | 0.76 | DRD3 (0.48) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7458210 | 0.75 | FYN (0.49) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7854684 | 0.74 | DRD3 (0.64) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL7854718 | 0.74 | DRD3 (0.64) | DRD3DRD2DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |