Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PAM | P19021 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050742 | 0.93 | CYP1A2 (0.52) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL11283053 | 0.88 | CYP1A2 (0.47) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL20398910 | 0.88 | TSHR (0.56) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL7522785 | 0.85 | L3MBTL1 (0.49) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL4864836 | 0.84 | CYP1A2 (0.47) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL2715956 | 0.84 | CYP1A2 (0.50) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL15009773 | 0.84 | CYP1A2 (0.50) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL10578789 | 0.84 | CYP1A2 (0.50) | TDP1CYP3A4TSHRATMCYP1A2 | |
| SCHEMBL1800630 | 0.84 | L3MBTL1 (0.51) | TDP1CYP3A4TSHRATMKMT2A | |
| SCHEMBL31530896 | 0.83 | DGKA (0.61) | TDP1CYP3A4TSHRATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |