Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612477 | 0.85 | LMNA (0.41) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL5903747 | 0.84 | LMNA (0.40) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL4745588 | 0.84 | PDE3A (0.45) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL27416424 | 0.81 | LMNA (0.38) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL30818468 | 0.78 | PDE3A (0.36) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL598527 | 0.78 | ABL1 (0.40) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL10513954 | 0.77 | DDB1 (0.36) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL3424602 | 0.77 | PDE3A (0.47) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL6882615 | 0.76 | LMNA (0.40) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL6858203 | 0.74 | FGFR1 (0.37) | LMNAPDE3ACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040297-A | A THERAPEUTIC AGENTS TREATING TUMORS AND RETROVIRAL INFECTIONS INCLUDING HIV INFECTIONS | BIOSEARCH ITALIA, S.P.A. (IT) | 2000-03-21 | — | — | US | disclosed |