Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418553 | 0.90 | ALDH1A1 (0.59) | FAAHALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL17874829 | 0.79 | TLR8 (0.52) | ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5717569 | 0.77 | LTB4R (0.48) | FAAHALDH1A1RAB9ASMN1; SMN2HTT | |
| SCHEMBL8112625 | 0.76 | FAAH (0.64) | FAAHALDH1A1GAA | |
| SCHEMBL8103726 | 0.76 | FAAH (0.64) | FAAHALDH1A1GAA | |
| SCHEMBL651699 | 0.76 | CYP2E1 (0.50) | FAAHALDH1A1RAB9A | |
| SCHEMBL9291482 | 0.76 | LTB4R (0.56) | FAAHALDH1A1SMN1; SMN2PTPN1LTB4R | |
| SCHEMBL8104256 | 0.75 | FAAH (0.63) | FAAHALDH1A1SMN1; SMN2HTTTNF | |
| SCHEMBL5717660 | 0.75 | CYP2A6 (0.59) | FAAHALDH1A1LTB4RTBXAS1 | |
| SCHEMBL15923223 | 0.75 | TLR8 (0.46) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |