Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104676 | 1.00 | CNR1 (0.45) | CNR1CNR2MTNR1AMTNR1BGAA | |
| SCHEMBL8097927 | 0.88 | MTNR1A (0.43) | CNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL8097924 | 0.88 | MTNR1A (0.43) | CNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL8097653 | 0.86 | SIRT2 (0.46) | CNR2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL8097656 | 0.86 | SIRT2 (0.46) | CNR2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL8096172 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8096171 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8097222 | 0.85 | MTNR1A (0.50) | MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL8088925 | 0.83 | HTR2A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8089150 | 0.83 | HTR2A (0.55) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |