Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.47 |
| ▸ | HTR2C | P28335 | 10/20 | 0.47 |
| ▸ | HTR2B | P41595 | 6/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104739 | 1.00 | HTR2A (0.47) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL8089391 | 0.86 | MTNR1B (0.52) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL8089388 | 0.86 | MTNR1B (0.52) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL8097743 | 0.84 | MTNR1B (0.51) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL8097747 | 0.84 | MTNR1B (0.51) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL8095790 | 0.84 | MTNR1A (0.47) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL23993612 | 0.76 | KDM1A (0.58) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL16591229 | 0.76 | KDM1A (0.58) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL706719 | 0.76 | KDM1A (0.58) | HTR2AHTR2CHTR2BKDM1AKDM1B | |
| SCHEMBL16585430 | 0.76 | KDM1A (0.58) | HTR2AHTR2CHTR2BKDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |