Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104871 | 0.81 | HPGD (0.40) | HRH3LMNASMN1; SMN2 | |
| SCHEMBL8104651 | 0.76 | HRH3 (0.37) | HRH3CARM1PRMT6PRMT8BACE1 | |
| SCHEMBL8095285 | 0.73 | HRH3 (0.39) | HRH3CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL7649942 | 0.72 | HRH3 (0.52) | HRH3CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL8471267 | 0.70 | HRH3 (0.56) | HRH3CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL7649376 | 0.70 | HRH3 (0.56) | HRH3SIGMAR1SMN1; SMN2ALOX15 | |
| SCHEMBL16312397 | 0.69 | HRH3 (0.61) | HRH3SIGMAR1SMN1; SMN2ALOX15 | |
| SCHEMBL3671614 | 0.68 | SIGMAR1 (0.46) | HRH3CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL24891390 | 0.66 | HRH3 (0.48) | HRH3CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL9927903 | 0.66 | HRH3 (0.48) | HRH3CARM1PRMT6PRMT8SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | claimed |
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |