Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 4/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199891 | 0.82 | MMP8 (0.44) | MMP8MMP3MEN1KMT2AALDH1A1 | |
| SCHEMBL2199884 | 0.82 | MMP8 (0.44) | MMP8MMP3MEN1KMT2AALDH1A1 | |
| SCHEMBL2200359 | 0.81 | MMP8 (0.47) | MMP8MMP3MEN1KMT2AALDH1A1 | |
| SCHEMBL2200364 | 0.81 | MMP8 (0.47) | MMP8MMP3MEN1KMT2AALDH1A1 | |
| SCHEMBL5717036 | 0.74 | HSD11B1 (0.74) | MEN1KMT2AALDH1A1HSD11B1PSEN1 | |
| SCHEMBL6410896 | 0.72 | HSD11B1 (0.48) | MMP3MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL7991187 | 0.72 | HSD11B1 (0.48) | MMP3MEN1KMT2AALDH1A1HSD11B1 | |
| Hydrochloric Acid SCHEMBL309182 | 0.71 | HSD11B1 (0.47) | MMP3MEN1KMT2AALDH1A1HSD11B1 | |
| Hydrochloric Acid SCHEMBL308298 | 0.71 | HSD11B1 (0.47) | MMP3MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL2170723 | 0.69 | HSD11B1 (0.49) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152713-B1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARM INC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2008147800-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |