Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9131931 | 0.82 | TRPA1 (0.55) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL17429778 | 0.79 | TSHR (0.49) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL19647227 | 0.78 | ALPI (0.52) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL12768183 | 0.78 | ALPI (0.52) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL5074359 | 0.77 | TSHR (0.48) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL883357 | 0.76 | SLC1A3 (0.63) | TRPA1SLC1A3SLC1A2SLC1A1NPC1 | |
| SCHEMBL5511480 | 0.76 | SLC1A3 (0.63) | TRPA1SLC1A3SLC1A2SLC1A1NPC1 | |
| SCHEMBL9513104 | 0.75 | CES2 (0.50) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL23960529 | 0.73 | EPHX1 (0.55) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL13588551 | 0.73 | EPHX1 (0.55) | TRPA1TAAR1SIGMAR1SLC6A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0532693-A1 | 1,4-DIAMINO-2,3-DIHYDROXYBUTANES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-24 | — | — | EP | disclosed |