Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12312536 | 0.91 | CYP2D6 (0.54) | RIPK1LMNAHTR2AHRH1KDM4E | |
| SCHEMBL12312535 | 0.91 | CYP2D6 (0.54) | RIPK1LMNAHTR2AHRH1KDM4E | |
| SCHEMBL10535014 | 0.91 | CYP2D6 (0.54) | RIPK1LMNAHTR2AHRH1KDM4E | |
| SCHEMBL11583588 | 0.85 | HTR2A (0.66) | LMNACACNA2D1HTR2AHRH1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11679206 | 0.83 | HTR2A (0.63) | LMNACACNA2D1HTR2AHRH1ALDH1A1 | |
| SCHEMBL3456875 | 0.82 | MEN1 (0.48) | LMNAKDM4EALDH1A1CYP3A4ADORA3 | |
| SCHEMBL1464023 | 0.79 | LMNA (0.53) | LMNAALDH1A1CYP2D6CYP3A4CHRM2 | |
| SCHEMBL8667358 | 0.79 | ALDH1A1 (0.51) | RIPK1LMNAHTR2AHRH1KDM4E | |
| SCHEMBL12312539 | 0.79 | TSHR (0.64) | LMNAKDM4EL3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL9183624 | 0.79 | TSHR (0.64) | LMNAKDM4EL3MBTL1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034272-A | CARDIOVASCULAR DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1998057929-A1 | ELEVATION OF HDL CHOLESTEROL BY N-[4-[ (AMINOTHIOXOMETHYL) HYDRAZONO] -4-ARYLBUTYL]AMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |