Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191899 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KDM4EL3MBTL1KCNH2RIPK1 | |
| SCHEMBL10251920 | 0.81 | AOC3 (0.58) | ALDH1A1AOC3KDM4EL3MBTL1RIPK1 | |
| SCHEMBL7298876 | 0.81 | AOC3 (0.58) | ALDH1A1AOC3KDM4EL3MBTL1RIPK1 | |
| SCHEMBL6705995 | 0.80 | KCNH2 (0.63) | ALDH1A1KCNH2LMNAGRIN1GRIN2A | |
| SCHEMBL31439743 | 0.80 | AOC3 (0.56) | ALDH1A1AOC3KDM4EL3MBTL1RIPK1 | |
| SCHEMBL1173367 | 0.79 | AOC3 (0.60) | ALDH1A1AOC3KDM4EL3MBTL1RIPK1 | |
| SCHEMBL5093264 | 0.79 | KDM4E (0.52) | ALDH1A1AOC3KDM4EL3MBTL1KCNH2 | |
| SCHEMBL8105954 | 0.79 | RIPK1 (0.50) | ALDH1A1AOC3KDM4EL3MBTL1KCNH2 | |
| SCHEMBL11251519 | 0.79 | MEN1 (0.41) | ALDH1A1KDM4EL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL17594805 | 0.77 | MAOA (0.60) | KDM4EL3MBTL1KCNH2LMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753660-A | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0715618-A1 | HYDROXYETHYLAMINO SULPHONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-06-12 | — | — | EP | disclosed |