Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.42 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110723 | 1.00 | AKR1C1 (0.57) | AKR1C1ALOX15CCR2OPRM1OPRL1 | |
| SCHEMBL8112628 | 1.00 | AKR1C1 (0.57) | AKR1C1ALOX15CCR2OPRM1OPRL1 | |
| SCHEMBL15215651 | 0.86 | ALOX15 (0.46) | AKR1C1ALOX15CCR2OPRM1OPRL1 | |
| SCHEMBL11490720 | 0.83 | AKR1C1 (0.39) | AKR1C1ALOX15CCR2OPRL1KMT2A | |
| SCHEMBL11481441 | 0.83 | CCR2 (0.51) | CCR2OPRM1OPRL1HDAC4KMT2A | |
| SCHEMBL11493927 | 0.83 | CCR2 (0.51) | AKR1C1CCR2OPRM1KMT2AMAOB | |
| SCHEMBL17222224 | 0.82 | AKR1C1 (0.59) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL15215644 | 0.82 | AKR1C1 (0.59) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL24662438 | 0.81 | NPY1R (0.40) | AKR1C1ALOX15CCR2OPRM1MAOB | |
| SCHEMBL25348737 | 0.81 | CHRNA1 (0.42) | AKR1C1ALOX15CCR2HDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124354-A | TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME | PHARMACIA & UPJOHN AB (SE) | 2000-09-26 | — | — | US | disclosed |
| EP-0923536-A1 | ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION | Pharmacia & Upjohn Aktiebolag (SE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998004517-A1 | ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION | PHARMACIA & UPJOHN AB (SE) | 1998-02-05 | — | — | WO | disclosed |